Blood Clotting Factors, Various Types, Effects, and Their Link with Deep Vein Thrombosis
The term thrombosis refers to the condition that a blood clotting factor molecule clogs up the blood vessels. Thrombosis is a complex biological process involving the blood vessel wall, calcium, and iron. Blood clotting factors have complex conformations that involve the proteins UL and VL. These clotting factors also interact with several other molecules that are involved in blood clotting such as fibrin. If a blood clotting factor molecule or a proenzyme collides with a fibrin molecule it can stop bleeding.
High prevalence of deep
vein thrombosis is expected to boost demand for blood clotting factors. According
to the Centers for Disease Control and Prevention (CDC), from 1998 to 2014,
around 900,000 people suffer from deep vein thrombosis (DVT)/ pulmonary
embolism each year in the U.S.
There
are several known blood clotting factors and there are several known risk
factors for developing thrombosis. Risk factors for developing thrombosis
include: hereditary clotting factors, hemorrhage, surgery, liver disease,
obesity, chronic venous insufficiency (or DI), and poor circulation. Some
people develop thrombosis due to factors associated with more commonly
occurring diseases such as those involving the kidneys, gallbladder, liver, and
pancreas. People with hemophilia are commonly affected by thrombosis due to the
deficiency of the factor viii, a protein needed for clotting. In addition,
thrombosis is most common in people with a history of spontaneous bleeding.
A
combination of factor viii and proenzyme Q10 has been shown to be very
effective in stopping the bleeding effect of thrombosis. Blood clotting factors
that do not produce any adverse side effects are considered fairly safe, and
are often recommended. As a matter of fact, there are currently a variety of
dietary supplements that are presently available to assist individuals who
suffer from hemophilia to stop bleeding. However, these products can only be
purchased by individuals who suffer from hemophilia and are within the age of
18 years.
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