High Prevalence of Heart Failure Leads to Various Clinical Trials Focusing On R&D of Effective Congestive Heart Failure Drugs

 

Congestive Heart Failure Drugs

Congestive heart failure drugs include beta blockers (carvedilol, metoprolol, bisoprilol), ACE inhibitors (lisinopril, captopril), angiotensin receptor blockers (losartan), combination medicines (Entresto, or sacubitril/valsartan), aldosterone antagonist (spironolactone, eplerenone), digoxin (Lanoxin), and others.

High prevalence of heart failure has led to various clinical trials focusing on R&D of congestive heart failure drugs. For instance, in November 2020, a clinical trial by Brigham and Women's Hospital and sponsored by Lexicon Pharmaceuticals, a biopharmaceutical company based in the U.S., reported that sotagliflozin, a combination sodium/glucose cotransporter 1 and 2 (SGLT1/2) inhibitor, resulted in a lower risk of the composite of deaths from cardiovascular causes, hospitalizations for heart failure, and urgent visits for heart failure than placebo.

ACE inhibitors are the most commonly used congestive heart failure drugs. They lower the heart rate and blood pressure, thereby reducing the number of heart attacks. However, there are a few negative side effects attached to using these medicines. Some patients suffer from renal failure, while some experience chest pain and dizziness. These medicines are also known to cause sexual dysfunction in some patients.

Other commonly prescribed medicines for congestive heart failure include angiotensin receptor blockers, calcium channel blockers, beta blockers and some diuretics. Although all of these medicines work to lower the blood pressure and reduce the number of heart attacks, the effects are generally temporary. This means that they will only help you for a short period of time. You have to continue taking the medication to achieve your goals. If you stop taking the medicine, the symptoms will return.

To avoid having long term complications from congestive heart failure drugs, it is best that you consult your doctor before taking any of these. If you are prescribed dilate blood vessels or ACE inhibitors, it is important that you follow your doctor's instructions carefully. Your doctor will teach you how to properly use these medicines. Also, it is essential that you learn as much as you can about heart problems and about ace inhibitors so that you know which one is the best for you.

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