High Prevalence of Heart Failure Leads to Various Clinical Trials Focusing On R&D of Effective Congestive Heart Failure Drugs
Congestive heart failure drugs include beta blockers (carvedilol, metoprolol, bisoprilol), ACE inhibitors (lisinopril, captopril), angiotensin receptor blockers (losartan), combination medicines (Entresto, or sacubitril/valsartan), aldosterone antagonist (spironolactone, eplerenone), digoxin (Lanoxin), and others.
High
prevalence of heart failure has led to various clinical trials focusing on
R&D of congestive heart failure drugs. For instance, in November 2020, a
clinical trial by Brigham and Women's Hospital and sponsored by Lexicon
Pharmaceuticals, a biopharmaceutical company based in the U.S., reported that
sotagliflozin, a combination sodium/glucose cotransporter 1 and 2 (SGLT1/2)
inhibitor, resulted in a lower risk of the composite of deaths from
cardiovascular causes, hospitalizations for heart failure, and urgent visits
for heart failure than placebo.
ACE
inhibitors are the most commonly used congestive heart failure drugs. They
lower the heart rate and blood pressure, thereby reducing the number of heart
attacks. However, there are a few negative side effects attached to using these
medicines. Some patients suffer from renal failure, while some experience chest
pain and dizziness. These medicines are also known to cause sexual dysfunction
in some patients.
Other
commonly prescribed medicines for congestive heart failure include angiotensin
receptor blockers, calcium channel blockers, beta blockers and some diuretics.
Although all of these medicines work to lower the blood pressure and reduce the
number of heart attacks, the effects are generally temporary. This means that
they will only help you for a short period of time. You have to continue taking
the medication to achieve your goals. If you stop taking the medicine, the
symptoms will return.
To
avoid having long term complications from congestive heart failure drugs, it is
best that you consult your doctor before taking any of these. If you are
prescribed dilate blood vessels or ACE inhibitors, it is important that you
follow your doctor's instructions carefully. Your doctor will teach you how to
properly use these medicines. Also, it is essential that you learn as much as
you can about heart problems and about ace inhibitors so that you know which
one is the best for you.
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